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Thyroid Dysfunction Associated with Dyslipidemi...
79,90 € *
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This book deals with analytical,epidemiological and socio-geographic studies of the relationship of several forms of thyroid dysfunction and their relationship to functioning of major organs of the body ,in particular liver and kidney.The book begins with a readable introduction to thyroid hormones,problems arising dysfunctions according to gender and age groups ,effect on serum lipids profile etc. The second chapter describes the basic methods ,patient selection and analytical methods for preparing samples and assaying levels of thyroid stimulating hormone,thyroxine,triiodothyronine, cholesterol, triglycerides, high and low density lipoproteins, creatinine and alanine amino transferase. The Third chapter presents the detailed analysis of the results in the form of well presented tables, and figures. These are then discussed presenting a careful analysis of the results, correlations and comparison with previously reported studies. The whole project is than summarized in a short but informative conclusion section ,along with a summary of limitations and some suggestion for further work.

Anbieter: Dodax
Stand: 05.06.2020
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Diagnostic Neuropathology
93,99 € *
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Every year dozens of physicians-in-training face, for the first time, the responsibil ity of examining and diagnosing central nervous system tumors or biopsies of the central nervous system, the peripheral nerves or muscles, whose surgical resection has been decided on both as a form of treatment (in the case of tumors) and as means to confirm a presumptive diagnosis. The selection of the most appropriate form of post surgical treatment for most tumors is predicated on the precise identification of the tumor cells. The evaluation of the specimen, by a pathologist, will not only determine whether the lesion is truly neoplastic, but also whether there are histologic indicators of malig nancy. Moreover, in some cases, the pathologist will be asked to determine whether the tumor cells contain certain hormone precursors or receptors, as an example. Recognition of many of the features that one must search for requires the judicious application of methods that may not be readily known to the physicians involved in the various diagnostic procedures. The handling and processing of the tissues as they arrive in the pathology laboratory for the above reasons vary as a function of the organ (or site) of origin of a given tumor as well as a function of the presumptive clinical diagnosis. The material contained in this book series has been organized in an attempt to help the pathologists-in-training, the general pathologists, the neurosurgeons, and neu rologists to understand the logic behind such special requirements.

Anbieter: Dodax
Stand: 05.06.2020
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Plant Chemical Genomics
117,69 € *
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Plant Chemical Genomics: Methods and Protocols , expert researchers in the field detail many of the techniques used for identification of bioactive compounds from a large selection of fields in plant biology including plant pathogenesis, immune responses, small RNA processing, endomembrane trafficking, lipids, plant hormone signaling and cell wall. The presentation of these and other examples as well as synthetic chemistry, computation and target identification provides a comprehensive overview of the practical aspects of chemical biology that are possible in plant systems. Small molecules and natural products that produce a phenotype in plants have been known for decades. The agrichemical industry has utilized small molecules based on known natural molecules such as auxins, cytokinins, abscissic acid and other growth regulators. In recent years, the screening and characterization of novel small molecules has enhanced our understanding of protein function, metabolic, signaling and endomembrane pathways, and their interactions in basic plant research. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Anbieter: Dodax
Stand: 05.06.2020
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Reducing Mortality in Critically Ill Patients
72,66 € *
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This book describes the techniques, strategies, and drugs that have been demonstrated by multicenter randomized trials to influence survival in critically ill patients, defined as those who have acute failure of at least one organ, due to either a pathological condition or a medical intervention, and require intensive care treatment. Each chapter focuses on a specific procedure, device, or drug. The scope is accordingly wide, with coverage of topics as diverse as noninvasive mechanical ventilation, protective ventilation, prone positioning, intravenous salbutamol in ARDS, high-frequency oscillatory ventilation, mild hypothermia after cardiac arrest, daily interruption of sedatives, tranexamic acid, diaspirin cross-linked hemoglobin, albumin, growth hormone, glutamine supplementation, tight glucose control, supranormal oxygen delivery, and hydroxyethyl starch in sepsis. The topic selection was made using a democracy-based approach in which hundreds of specialists from dozens of countries expressed, via the web, whether they agreed with these topics and whether they used the techniques in their daily clinical practice. The clear text is supported by "how to do" sections and "key point" boxes that provide easily accessible practical information. The book will be of interest for a wide variety of specialists, including intensivists, emergency doctors, and anesthesiologists.

Anbieter: Dodax
Stand: 05.06.2020
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Evaluation of indigenous sistani cattle using b...
49,00 € *
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The objective of this M.sc dissertation is about Sistani cattle as one of the most important cattle in the country of Iran. Evaluation of quantitative and molecular genetic approach is required for designing of any breeding strategy in this breed. This dissertation tried to review the application of Biotechnological methods in animal science with emphasis on concepts of candidate gene and DNA marker technology. Growth hormone and its receptor gene polymorphism provide useful information for estimation of breeding value for growth trait and could be appreciable for overcome to some of the limitation of the conventional selection methods.

Anbieter: Dodax
Stand: 05.06.2020
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Recent Trends in Mastalgia
59,00 € *
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Mastalgia is the commonest breast symptom presenting to general practitioners and breast surgeon alike. Two out of three women suffer from breast pain at sometime in their lives. Like any other breast problem, it can be worrying, but most breast pain can be treated easily.Women with severe, sustained breast pain that interferes with their quality of life may benefit from treatment with low-dose or luteal-phase medications such as danazol or tamoxifen. These medications have proven effectiveness, however, their benefit in ameliorating breast discomfort and pain must be balanced against their potential adverse effects. Selection of a specific agent is individualized. In certain circumstances, bromocriptine or a gonadotropin-releasing hormone agonist may be needed, however, approaches to decreased dosing to minimize adverse effects have not been established. To make a full assessment of the cause, all patients require a full history, examination and, sometimes, investigations. Dairy cards are often helpful. The commonest cause is cyclical mastalgia. Most women require reassurance only and the pain often settles spontaneously after few months.

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Principles of Receptor Research
168,00 CHF *
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1 Blood-Brain Barrier: Techniques for the Intracerebral Administration of Drugs.- 1. Introduction.- 2. Characteristics of the Blood-Brain Barrier.- 2.1. Specific Activity of the Blood-Brain Barrier.- 2.2. Breakdown of the Blood-Brain Barrier.- 2.3. The Brain-CSF Barrier.- 3. Bypassing the Blood-Brain Barrier: Principles.- 4. Pharmacological Approach to the Internal or External Surface of the Brain.- 4.1. Drugs Applied to the Surface of the Cortex.- 4.2. Administration of a Drug into the Cerebral Ventricles.- 4.3. Perfusion of Brain Surfaces.- 5. Drugs Administered to the Brain Parenchyma.- 5.1. Injection of Solution.- 5.2. Depositing a Chemical in Crystalline Form.- 5.3. Isolated Perfusion with Push-Pull Cannulae.- 6. Concluding Comment.- 7. References.- 2 Microiontophoretic Application of Drugs onto Single Neurons.- 1. Introduction.- 2. Basic Principles.- 2.1. Spontaneous Efflux of Active Material from Microelectrodes.- 2.2. Release of Ionized Substances During Passage of Iontophoretic Current.- 2.3. Electro-osmosis.- 2.4. Microinjection.- 3. Dispersal of Iontophoretically Applied Substances Within the Brain.- 3.1. Theoretical Curves Based on Models of Diffusion.- 3.2. Tissue Uptake Mechanisms and Drug Redistribution.- 4. Conclusions.- 5. References.- 3 Electrical Recording of Brain Activity: The EEG and Its Value in Assessing Drug Effects.- 1. Introduction.- 2. Selection of Animal Species.- 3. Acute Experiments.- 4. Chronic Implantation of Electrodes.- 5. Recording Procedures.- 5.1. Experiments in Animals with Chronic Implants.- 5.2. Human Studies.- 5.3. Derivations.- 5.4. Amplifiers.- 5.5. Paper Records.- 5.6. Magnetic Tape Recording.- 6. Methods of Analyzing and Quantifying the EEG.- 6.1. Hand Analysis.- 6.2. Integration.- 6.3. Frequency Analysis.- 6.4. Spectral Analysis.- 6.5. Correlation Procedures.- 7. Sensory Evoked Response Analysis.- 7.1. Visual Evoked Responses.- 7.2. Somatosensory Evoked Responses.- 7.3. Auditory Evoked Responses.- 8. Focal Electrical Stimulation.- 9. Electrogenesis of the EEG and Evoked Potentials.- 10. Assessment of Alertness, Sedation, and the Stages of Sleep.- 11. Study of Sleep Patterns.- 12. Abnormal EEG Records.- 12.1. Normal Rhythms Occurring Abnormally.- 12.2. Nonepileptic Abnormal Rhythms.- 12.3. Epileptic Features.- 13. Transmitters and EEG Changes.- 13.1. Acetylcholine.- 13.2. Catecholamines.- 13.3. 5-Hydroxytryptamine.- 13.4. ?-Aminobutyric Acid.- 14. Uses and Limitations of Macroelectrode Recordings.- 15. References.- 4 Neuropharmacological Responses from Nerve Cells in Tissue Culture.- 1. Introduction.- 2. Muscle.- 3. Continuous Cell Lines.- 4. Glia.- 5. Explants.- 6. Dissociated Primary Cell Cultures.- 7. Discussion.- 8. References.- 5 Biochemical Identification of Membrane Receptors: Principles and Techniques.- 1. Introduction.- 2. Properties of Receptor Interactions and Technical Considerations.- 2.1. Number and Affinity of Membrane Receptors.- 2.2. Preparation of Radioactive Ligand Derivatives.- 2.3. Rates of Association and Dissociation.- 2.4. Competitive Antagonists as Tools for Binding Studies.- 2.5. The Problem of Specific vs. Nonspecific Binding.- 2.6. Methods of Obtaining Binding Data.- 2.7. Measurements on Solubilized Receptors.- 2.8. Membrane Receptors and Proteolytic Agents.- 2.9. Comparative Studies of Ligand-Membrane Interactions.- 2.10. Other Methods for the Study of Ligand-Receptor Interactions.- 2.11. Mathematical Analysis of Binding Data.- 3. Examples of Studies on Hormone-Membrane Receptor Interactions.- 3.1. Insulin-Receptor Interaction in Fat and Liver Cells.- 3.2. Insulin Receptors in Human Lymphocytes and Fibroblasts.- 3.3. Insulin-like Activity and Binding of Plant Lectins.- 3.4. Glucagon Binding and Action in Liver Membranes.- 3.5. Epidermal Growth Factor Receptors in Human Fibroblasts.- 3.6. Catecholamine Binding and ?-Adrenergic Receptors.- 3.7. Macromolecular Hormone Derivatives and Plasma Membrane Receptors.- 4. Conclusions.- 5. References.- 6 Structure-Activity Relations for Neurotransmitter Receptor Agonists and Antagonists.- 1. Introduction.- 2. Norepinephrine.- 2.1. Peripheral Nervous System.- 2.2. Adrenergic Receptors in the CNS.- 2.3. Possible Modes of Action.- 2.4. Crystallographic, NMR, and Theoretical Studies of the Conformation of NE

Anbieter: Orell Fuessli CH
Stand: 05.06.2020
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Thyroid Function Testing
273,00 CHF *
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Thyroid function tests are utilized by essentially all medical practitioners, across every clinical setting, in patients from newborns to the elderly. They are the most frequently measured endocrine tests. The sensitive thyrotropin (TSH) assay reflects thyroid hormone feedback to the pituitary, and is diagnostic of both thyroid h- mone excess as well as deficiency. The log–linear relationship between serum TSH and thyroxine concentrations means that small changes in serum thyroxine are amplified by changes in serum TSH. The availability of the sensitive TSH assay in essentially all clinical laboratories has improved and simplified the assessment of thyroid function for the diagnosis of thyroid disease and to monitor treatment. Serum free thyroxine and thyrotropin concentrations, as well as other thyroid tests, can be measured utilizing an automated immunoassay platform that provides rapid and accurate results. This simplified approach to thyroid assessment, often requ- ing only a serum TSH measurement, and rapid availability of the thyroid function tests results, has expanded the scope of thyroid testing and clinicians ordering and interpretingth yroid tests. There remain, however, many challenges in selecting the appropriate thyroid function test to order, the correct interpretation of results, and applying these results to the diagnosis and management of thyroid diseases. It is especially important to be aware of limitations of thyroid function tests, as well as special clinical c- cumstances that can influence thyroid function measurements. The serum TSH concentration, for example, may not accurately reflect thyroid status in many si- ations including after prolonged hyperthyroidism when serum TSH remains s- pressed for months, in the presence of hypothalamic or pituitary disease, or due to a number of interfering medications. The serum free thyroxine, measured by the analog method, is not accurate with high or low serum binding proteins and d- ing pregnancy. Hospitalized patients often have thyroid function test abnormalities that are transient and return to normal after recovery from the acute illness. Iodine excessand deficiency candramatically influence thyroid function tests. Significant insights have been gained into the regulation of thyroid hormone synthesis and especially the role of thyroid hormone metabolism in supplying t- sues locally with an adequate supply of thyroid hormone. In a number of instances, these factors influence the selection and interpretation of thyroid function tests. Polymorphisms, common sequence variations, in genes of components that regulate thyroid function and thyroid hormone action may also contribute to variability in thyroid function tests in a population. v vi Preface This volume draws on an outstanding international panel of experts in thyroid function tests and thyroid function assessment. They represent clinicians, clinical researchers, and basic science researchers, all with a focus on some aspect of the assessment of thyroid function. The chapters all provide a clinical perspective, but are informed by themost recent scientific advancements. The first section of the book (Chaps. 1–3) presents the most recent advances in thyroid physiology, a review of genetic influences on thyroid function tests, and a discussion on the influence of iodine on thyroid function. In Chap. 1, Drs. Huang and de Castro Neves describe thyroid hormone metabolism, emphasizing the key role of thyroid hormone activation and inactivation in thyroid hormone action. Dr. Visser is a world leader in studies of thyroid metabolism and genetic influences on thyroid function. In Chap. 2, Dr. Visser and his colleagues, Drs. van der Deure, Medici, and Peeters, provide a clear view of this important and r- idly expanding field. The population variation in the TSH “set point” (relationship between serum TSH and thyroxine in an individual), for example, is thought to be genetically determined, and influences the evaluation of thyroid function and thyroid function targets for treatment of thyroid disease. Dr. Zimmerman, an int- nationally recognized expert in iodine, and his colleague, Dr. Andersson, provide in Chap. 3 an in-depth treatment of the most significant influence

Anbieter: Orell Fuessli CH
Stand: 05.06.2020
Zum Angebot
Diagnostic Neuropathology
106,00 CHF *
ggf. zzgl. Versand

Every year dozens of physicians-in-training face, for the first time, the responsibil ity of examining and diagnosing central nervous system tumors or biopsies of the central nervous system, the peripheral nerves or muscles, whose surgical resection has been decided on both as a form of treatment (in the case of tumors) and as means to confirm a presumptive diagnosis. The selection of the most appropriate form of post surgical treatment for most tumors is predicated on the precise identification of the tumor cells. The evaluation of the specimen, by a pathologist, will not only determine whether the lesion is truly neoplastic, but also whether there are histologic indicators of malig nancy. Moreover, in some cases, the pathologist will be asked to determine whether the tumor cells contain certain hormone precursors or receptors, as an example. Recognition of many of the features that one must search for requires the judicious application of methods that may not be readily known to the physicians involved in the various diagnostic procedures. The handling and processing of the tissues as they arrive in the pathology laboratory for the above reasons vary as a function of the organ (or site) of origin of a given tumor as well as a function of the presumptive clinical diagnosis. The material contained in this book series has been organized in an attempt to help the pathologists-in-training, the general pathologists, the neurosurgeons, and neu rologists to understand the logic behind such special requirements.

Anbieter: Orell Fuessli CH
Stand: 05.06.2020
Zum Angebot